糖尿病肾病患者与炎症因子及胰岛素抵抗关系的研究

The Relationship between inflammatory cytokines or the insulin resistance and diabetic nephropathy

目的探讨糖尿病肾病与炎症因子、胰岛素抵抗的关系。方法对120例2型糖尿病患者的代谢指标及炎症因子水平进行分析比较,并按尿白蛋白排泄率(UAER)将患者分为正常白蛋白尿组(A组41例)、微量白蛋白尿组(B组47例)和临床蛋白尿组(C组32例)。结果C组、B组的炎症因子水平、空腹胰岛素(FINS)水平均高于A组的糖尿病患者(P<0.01,P<0.05);C组、B组的胰岛素敏感指数(ISI)较A组明显降低(P<0.01)。结论炎症因子及胰岛素抵抗与糖尿病肾病密切相关。

Objective To study the relationship between the inflammatory eytokines or the insulin resistance （IR） and diabetic nephropathy （DN）. Methods The metabolic data and the serum levels of inflammlatory cytokines of 120 type T2DM were collected and analyzed with multivariable stepwise regression statistical method. The patients were divided into three groups according to albumin excretion rate （UAER）. （1） Group A： 41 patients with normal UAER. （2） Group B： 47 patients with tractive UAER. （3） Group C： 32 patients with big UAER. Results The serum levels of inflammlatory cytokines and fasting insulin in group C and group B were significantly higher than that in group A （P〈0.01, P〈0.05）, but insulin sensitivity index （ISI） in group C and group B were significantly lower than that in group A （P〈0.01）. Conchusion The inflammatory cytokines or IR may be related to DN.