摘要
Gap junctions are intercellular channels, which connect adjacent cells and allow direct molecular exchange of low molecular weight between them. Three protein families including connexins, innexins and ponnexins are involved in gap junctions. Connexins are only found in chordate and innexins compose the gap junctions of invertebrates, while pannexins are ubiquitous and present in both vertebrates and invertebrates. Gap junctions in metazoan play important roles in electrical coupling, regulating proliferation, differentiation, and embryonic development. Evidently, the defects of gap junctions resulting form proteins contribute to many diseases of vertebrates and invertebrates, such as tumor, heart diseases, nervous system disorders and other diseases in human.
Gap junctions are intercellular channels, which connect adjacent cells and allow direct molecular exchange of low molecular weight between them. Three protein families including connexins, innexins and Ponnexins are involved in gap junctions. Connexins are only found in chordate and innexins compose the gap junctions of invertebrates, while pannexins are ubiquitous and present in both vertebrates and invertebrates. Gap junctions in metazoan play important roles in electrical coupling, regulating proliferation, differentiation, and embryonic development. Evidently, the defects of gap junctions resulting form proteins contribute to many diseases of vertebrates and invertebrates, such as tumor, heart diseases, nervous system disorders and other diseases in human.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2007年第6期1240-1243,共4页
Chinese Journal of Pathophysiology
基金
广东省自然科学基金团队项目(No.039213)
广州市科技计划项目(No.2004J1-C0214)
