手性pybox-金属络合物及其在不对称催化反应中的应用

The Chiral Metal Complexes of Pyridine-2,6-bis(oxazolines) and Their Applications in Catalytic Asymmetric Reactions

具有C2对称性的双唑啉型吡啶(pybox)是一类有效的手性配体,能与许多金属离子配位,其手性催化性能已得到越来越多的关注。本文综述了手性配体pybox和pybox-金属络合物的合成方法,特别是近年来pybox-金属络合物在不对称催化反应如不对称环丙烷化反应、不对称Diels-Alder反应、1,3-偶极环加成反应、不对称aldol反应等中应用的最新进展。

Pyridine-2,6-bis（oxazolines） （pybox） which has C2-symmetry is a kind of effective chiral ligands. It can coordinate with many metal cations. Asymmetric catalysis with chiral pybox complexes has received considerable attention in recent years. In this paper the preparation of chiral pybox ligands and their metal complexes are reviewed, especially the application of chiral pybox-metal complexes in catalytic asymmetric reactions such as asymmetric cyclopropanation reactions, asymmetric Diels-Alder reactions, 1,3-dipolar cycloaddition reactions, asymmetric aldol addition reactions and so on in recent years.