摘要
本文综述了聚乙二醇与聚乳酸共聚亲水改性的最新进展,包括嵌段和星型结构聚乙二醇-聚乳酸共聚物(PEG-PLA)及其端基化衍生物的合成。同时概述了该共聚物以胶束、微粒、水凝胶和囊泡形式担载亲水、疏水及蛋白类药物的应用,特别介绍了静电纺丝法制备的PEG-PLA超细纤维载体及其释药特性。
Recent progress in hydrophilic modification of poly （lactic acid） copolymerized with poly （ethylene glycol） is reviewed in this paper. Synthesis methods of poly（ ethylene glycol）-poly（lactic acid） copolymers （PEG-PLA） with block or star structures and their terminated derivatives, including their applications in loading hydrophilic, hydrophobic or protein drugs in forms of micelle, microparticle, hydrogel and vesicle are summaried. Especially, drug release behaviors of ultrafine PEG-PLA fibers prepared by electrospinning for drug carriers are introduced.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2007年第6期973-981,共9页
Progress in Chemistry
基金
国家自然科学基金项目(No.50573055)资助
关键词
聚乙二醇-聚乳酸共聚物
药物载体
控制释放
静电纺丝
poly （ ethylene glycol ）-poly （ lactic acid ） copolymers
drug carriers
controlled release
electrospinning
