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NKG2D及其配体在白血病免疫监视中的作用 被引量：1

Role of NKG2D and its ligands in leukemia immune surveillance
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摘要 NKG2D是免疫细胞表面的激活性受体,在机体的抗肿瘤免疫、抗感染免疫以及自身免疫病的发生中发挥重要作用。NKG2D识别肿瘤细胞表面的配体,激活效应细胞,产生有效的抗肿瘤免疫应答,是肿瘤免疫监视机制之一。近来研究发现白血病细胞表达多种NKG2D配体,参与白血病的免疫监视。本文就NKG2D及其配体对白血病免疫监视和免疫逃逸的作用作一综述。 NKG2D, an activating immunoreceptor, plays a critical role in tumor immunity, infection immunity and autoimmune diseases. Engagement of NKG2D ligands on tumor cells by NKG2D triggers effector cells to eliminate tumor cells. This leads to the hypothesis that NKG2D-mediated cytolytic function could be one of the mechanisms of tumor immune surveillance. Currently intensive researches have shown that NKG2D ligands expressed on leukemia cells are involved in leukemia immune surveillance. This review summarizes some of recent discoveries about the roles of NKG2D and its ligands in immune surveillance and immune evasion of leukemia.
作者 刘慧英 孙昭 赵春华
机构地区 中国医学科学院中国协和医科大学基础医学研究所组织工程研究中心
出处 《基础医学与临床》 CSCD 北大核心 2007年第5期588-592,共5页 Basic and Clinical Medicine
关键词 NKG2D 白血病 免疫监视 免疫逃逸 NKG2D leukemia immune surveillance immune evasion
分类号 R733.7 [医药卫生—肿瘤]
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参考文献24

  • 1Houchins J, Yabe T, McSherry C, et al. DNA sequence analysis of NKG2, a family of related cDNA clones encoding type Ⅱ integral membrane proteins on human natural killer cells[J]. J Exp Med, 1991, 173:1017 -1020.
  • 2Groh V, Steinle A, Bauer S, et al. Recognition of stressinduced MHC molecules by intestinal epithelial gammadelta T cells[J]. Science, 1998, 279:1737 - 1740.
  • 3Watson N, Spendlove I, Madjd Z, et al. Expression of the stressrelated MHC class Ⅰ chain-related protein MICA is an indicator of good prognosis in colorectal cancer patients[J]. Int J Cancer, 2006,118 : 1445 - 1452.
  • 4Salih H, Antropius H, Gieseke F, et al. Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia[J]. Blood, 2003, 102:1389- 1396.
  • 5Mizutani K, Terasaki P, Bignon J, et al. Association of kidney transplant failure and antibodies against MICA [J]. Hum Immunol, 2006,67:683 - 691.
  • 6Cosman D, Mullberg J, Sutherland C, et al. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D recepto [J]. Immunity, 2001, 14:123-133.
  • 7Chalupny N, Sutherland C, Lawrence W, et al. ULBP4 is a novel ligand for human NKG2D [ J ]. Biochem Biophys Res Commun, 2003, 305:129- 135.
  • 8Rolle A, Mousavi-Jazi M, Eriksson M, et al. Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein[J]. J Immunol, 2003,171:902 -908.
  • 9Diefenbach A, Jamieson A, Liu S, et al. Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages [ J ]. Nat Immunol, 2000, 1:119 - 126.
  • 10Carayannopoulos L, Naidenko O, Fremont D, et al. Cutting edge: mufine UL16-binding protein-like transcript 1 : a newly described transcript encoding a high-affinity ligand for murine NKG2D[J]. J Immunol, 2002, 169:4079 - 4083.

同被引文献10

  • 1Nagira M, Imai T, Hieshima K, et al. Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13 [J]. J Biol Chem, 1997, 272(31) : 19518 - 19524.
  • 2Kwan J, Killeen N. CCR7 directs the migration of thymocytes into the thymic medulla [J]. J Immunol, 2004, 172 (7) :3999-4007.
  • 3Ueno T, Saito F, Gray DH,et al. CCR7 signals are essential for cortex-medulla migration of developing thymocytes [J]. J Exp Med, 2004, 200(4) :493-505.
  • 4Balkwill F. Cancer and the chemokine network[J]. Nat Rev Cancer,2004,4 : 540 - 550
  • 5Kakinuma T, Hwang ST. Chemokines, chemokine receptors, and cancer metastasis [ J ]. J Leukoc Biol, 2006, 79 (4) :639-651.
  • 6Eo SK, Lee S, Kumaraguru U,et al. Immunopotentiation of DNA vaccine against herpes simplex virus via co2delivery of plasmid DNA expressing CCR7 ligands [ J ]. Vaccine, 2001,19 (32) :4685-4693.
  • 7Robertson MJ. Role of chemokines in the biology of natural killer cells [J]. J Leukoc Biol, 2002,71 (2) :173-183.
  • 8Ahmadzadeh M, Rosenberg SA. TGF-beta 1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cells [ J ]. J Immunol, 2005, 174(9) :5215-5223.
  • 9Andersen MH, Becker JC, Straten P. Regulators of apoptosis: suitable targets for immune therapy of cancer [J]. Nat Rev Drug Discov, 2005, 4(5):399-409.
  • 10Srivastava NA, Gupta S, Mukhtar H. Involvement of BCL- 2 and Bax in Photodynamic Therapy-mediated Apoptosis: ANTISENSE BCL-2 oligonucleotide sensitizes rill cells to photodynamic therapy apoptosis [J]. J Biol Chem, 2001, 276(18) :15481 - 15488.

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基础医学与临床
2007年 第5期

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