中医扶正健脾法配合化疗治疗小儿实体肿瘤的临床观察

Effect of Supporting the Healthy Energy and Strengthening Pi Principle of TCM Combined with Chemotherapy in Treating Children with Solid Tumors

目的探讨采用中医扶正健脾方法配合小儿实体瘤化疗,减轻化疗所致不良反应,改善化疗患儿生活质量的临床应用价值。方法采用前瞻性队列研究,选取60例正在进行化疗的Ⅱ-Ⅳ期实体瘤患儿分为两组,观察组30例,化疗加中医辨证分型治疗;对照组30例,单纯化疗;对两组化疗后6个月时情况进行比较。结果观察组治疗后白细胞、血红蛋白及血小板均较治疗前升高（P〈0.01,P〈0.01,P〈0.05）;对照组治疗后白细胞及血红蛋与治疗前比较,差异无显著性（P〉0.05）,血小板降低（P〈0.05）。观察组治疗后临床症状评分与对照组比较,差异有显著性（P〈0.05）。结论中医扶正健脾、补益气血的方法,对于改善实体瘤化疗患儿的不良反应症状及改善末梢血象具有较好疗效。

Objective To study the clinical validity in improving quality of life .（QOL） of patients and alleviating adverse reaction of chemotherapy in treating children with solid tumors by Chinese herbal medicine for supporting healthy energy and strengthening Pi. Methods A prospective cohort study was conducted in 60 children with solid tumor in stage Ⅱ -Ⅳ, who were assigned to two groups, 30 in each group. All children received chemotherapy and those in the observed group were given Chinese herbs according to syndrome differentiation additionally, The conditions of the two groups were compared after 6-month treatment. Results Compared with before treatment, the white blood cells （WBC）, hemoglobin （Hb）, and platelet （PLT） all increased in the observed group after treatment （P〈0.01, P〈0.01, P〈0.05）, while in the control group, the WBC and Hb have no significant difference （P〉0.05） and PLT decreased （P〈0.05） after treatment. Comparison between the two groups, the clinical symptom score in the observed group has significant difference after treatment （P〈0.05）. Conclusion Chinese herbal medicine for supporting healthy energy, strengthening Pi and supplementing qi-blood is good for alleviating the adverse reaction and improving patients＇ peripheral blood picture in children with solid tumor undergoing chemotherapy.