参芪扶正注射液对体外循环术后红细胞免疫功能的影响

Clinical Study on Effect of Shenqi Fuzheng Injection on Erythrocyte Immunity in Patients after Cardiopulmonary Bypass

目的探讨参芪扶正注射液(简称参芪液)对体外循环(CPB)术后患者红细胞免疫功能的影响。方法选取20例体外循环手术患者,分为参芪液组与对照组(每组10例)。参芪液组于术前5天开始及术中体外循环结束时每日静脉滴注参芪液250mL。于麻醉前、术后6h、24h、72h及7d抽取肝素抗凝的外周静脉血,动态检测两组患者红细胞C3b受体花环率(RBC-C3bRR)、红细胞免疫复合物花环率(RBC-ICR)。结果参芪液组患者RBC-C3bRR、RBC-ICR术后6h、24h、72h及7d明显高于对照组,并且于术后7d恢复到正常水平,红细胞免疫功能明显优于对照组患者(P<0.05)。结论CPB可以导致红细胞免疫功能低下,围术期应用参芪扶正注射液能明显改善CPB患者术后红细胞的免疫功能,促进受损红细胞免疫功能的恢复。

Objective To study the effect of Shenqi Fuzheng Injection （SQFZI） on erythrocyte immune function in patients after cardiopulmonary bypass （CPB）. Methods Twenty patients ready for receiving CPB were randomly assigned to two groups, 10 in each group. Patients in the SQFZI group were treated with 250 mL SQFZI via intravenous dripping starting from 5 days before operation and after ending CPB once a day. Peripheral venous blood samples of all patients were collected at the time points of before anesthesia, and 6 h, 24 h, 72 h and 7days after CPB, which were anticoagulated with heparin for dynamically detecting the changes of RBC-C3bRR and RBC-ICR. Results RBC-C3bRR and RBC-ICR in the SQFZI group were significantly higher at 6 h, 24 h, 72 h, and day 7 after operation than those in the control group respectively at the corresponding time points, and they restored to the normal levels at day 7, suggesting the erythrocyte immune function after CPB in the SQFZI group was superior to that in the control group （P 〈 0.05）. Conclusion Application of SQFZI in the peri-operative period can significantly improve the hypo-immunological function of erythrocyte caused by CPB, and promote the recovery of erythrocyte immunity.