摘要
目的:探讨慢性肝病患者血清Ⅲ型前胶原(PCⅢ)水平与肝纤维化病变程度的相关性及进程的分级判定作用。方法:采用放射免疫分析(RIA)与自动生化仪化学法测定70例正常对照(仅测定PCⅢ水平)、32例慢性中度乙肝、27例慢性重度乙肝、27例肝炎肝硬化、39例原发性肝癌血清中PCⅢ的含量和肝功能相关酶,如丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)活性以及其他常规肝功能项目,如总胆红素(STB)、直接胆红素(SDB)、总蛋白(TP)、白蛋白(ALB)、总胆汁酸(TBA),分析不同组别的血清PCⅢ水平与肝纤维化程度的相关性及与其他检测项目的关系。结果:①血清PCⅢ水平依次为:慢性重度乙肝组(n=27,501.17±191.09)>肝炎肝硬化组(n=27,334.52±139.14)>正常对照组(n=32,298.02±151.02)>原发性肝癌组(n=39,281.42±143.48)>正常对照组(n=70,122.56±92.94);②慢性重度乙肝组血清PCⅢ水平与STB和SDB正相关(均P<0.05),与ALP显著正相关(P<0.01);③肝炎肝硬化组PCⅢ与STB、SDB、TBA及ALP显著正相关(均P<0.01);④慢性中度乙肝组血清PCⅢ水平与AST及ALP显著正相关(均P<0.01);⑤原发性肝癌组的血清PCⅢ与STB、SDB、TBA、AST及ALP显著正相关(均P<0.01)。结论:血清PCⅢ水平可反映肝纤维化的活跃状态,而非肝纤维化的最终病变程度。
Objective To study the correlation between serum level of PC Ⅲ and the degree of liver fibrosis in patients with chronic liver diseases. Methods Serum level of PC Ⅲ was assayed with RIA and other markers of liver function ( including ALT, AST, STB, SDB, TP, ALB, TBA) were assayed with automatic biochemical analyzer in 188 patients with various chronic liver drseases. PC Ⅲ only were examined in 70 controls. Results ① The serum levels of PC Ⅲ were in this order: chronic severe hepatitis ( n = 27, 501.17 + 191.09) 〉 liver cirrhosis from chronic hepatitis( n = 27,334.52 + 139.14) 〉 chronic moderate hepatitis (n = 32,298.02 + 151.02) 〉primary liver cancer (n =39,281.42 +143.48) 〉normal controls (n =70,122.56 +92.94). ②The serum levels of PC Ⅲ were positively correlated with STB and SDB levels (P 〈0.05 ) in patients with chronic severe hepatitis and was significantly positively correlated with ALP levels (P 〈 0.01 ).③ The serum level of PC Ⅲ were significantly positively correlated with STB, SDB, TBA and ALP in patients with cirrhosis from chronic hepatitis (P 〈0.01 ). ④The serum levels of PCⅢ were significantly positively correlated with AST and ALP levels in patients with chronic moderate hepatitis (P 〈 0.01 ). ⑤ The serum levels of PC Ⅲ were significantly positively correlated with STB, SDB, TBA, AST and ALP in patients with primary liver cancer (P 〈 0.01 ). Conclusion Serum level of PC Ⅲ might adequately reflect the activity of the process of hepatic fibrosis, but did not necessarily reflect the degree of fibrosis already attained.
出处
《放射免疫学杂志》
CAS
2007年第3期195-198,共4页
Journal of Radioimmanology