结肠癌患者血清VEGF、CEA检测的临床意义

Clinical Significance of Determination of Serum VEGF and CEA Levels in Patients with Colorectal Cancer

目的:研究血清VEGF和CEA检测在结肠癌诊断中的联合应用价值,以及VEGF含量与肿瘤分期的关系。方法:收集结肠癌患者及正常人静脉血标本,应用ELISA检测血清VEGF含量,用放射免疫分析CEA含量。结果:血清VEGF和CEA检测在结肠癌患者术前的诊断阳性率分别为53.6%(15/28)和39.3%(11/28),二者联合诊断的阳性率为71.4%,且血清VEGF含量未降至正常的患者90%出现复发转移,本文研究同样表明结肠癌患者血清中VEGF含量与Duke’s分期呈显著相关。而且与血清CEA呈显著正相关(P<0.05)。结论:血清VEGF与CEA联检可提高结肠癌患者的检出率,VEGF含量与结肠癌的临床分期呈正相关,VEGF及CEA的高表达可能提示肿瘤生长活跃。

Objective To study the applicability of combined determination of serum VEGF and CEA levels in the diagnosis of colorectal cancer as well as the relationship between VEGF level and stage of the disease. Methods Serum VEGF （with ELISA） and CEA （with RIA） levels serum were detected in 28 patients with colorectal cancer of various stages and 29 controls. Results The diagnostic positive rate was 53.6% （15/28）, 39.3% （11/28 ）, 71.4% （20/28） with CEA, VEGF and combined test for colorectal cancer, respectively. The serum VEGF levels in patients with advance colorectal cancer were significantly higher than those in patients with earlier stages diseases and controls, VEGF levels were positively correlated with CEA levels （ P 〈 0.05 ）. Conclusion Combined detection of the levels of serum VEGF and CEA could improve significantly the diagnostic positive rate in patients with colorectal caneer.