EH和CHD患者血浆皮质醇节律表达水平的临床分析

Study on the Rhythmic Variation of Plasma Cortisol Levels in Patients with Essential Hypertension (EH) and Coronary Heart Disease (CHD)

目的:通过对原发性高血压(EH)和冠心病(CHD)患者的血浆皮质醇节律表达水平的分析,探讨EH、CHD患者的发病因素和机理。方法:检测EH61例、CHD46例和健康对照组36例的血浆皮质醇,并进行比较。结果:EH和CHD患者血浆皮质醇节律明显高于正常对照组(P<0.01)。结论:血浆皮质醇节律升高可能是EH和CHD发病因素之一。

Objective To study the rhythmic fluctuation of plasma cortisol levels in patients with EH and CHD. Methods Plasma cortisol levels were determined with RIA at 8Am, 4Pm and midnight in 61 patients with EH, 46 patients with CHD and 36 controls. Results The normal rhythmic fluctuation pattern of plasma cortisol levels was retained in the EH and CHD patients. However, the levels were all significantly higher in the patients than those in the controls, especially in the midnight specimens. Conclusion Marked elevated plasma cortisol levels were observed in patients with EH and CHD, with the normal rhythmic fluctuation pattern retained.