加味黄芪桂枝五物汤防治希罗达相关性手足综合征的临床观察

Clinial Study of Jiawei Huangqi Guizhi Wuwu Decoction on Prevention of Hand-foot Syndrome Caused by Xeloda

目的:观察中药加味黄芪桂枝五物汤防治希罗达相关性手足综合征的临床疗效。方法:53例患者随机分为治疗组29例和对照组24例,治疗组在化疗同时口服加味黄芪桂枝五物汤,每日1剂,对照组常规化疗,观察2组手足综合征的发生情况。结果:治疗组手足综合征的发生率34.5%,对照组手足综合征的发生率58.3%,2组比较差异有显著性(P<0.05)。结论:加味黄芪桂枝五物汤对防治希罗达相关性手足综合征有一定疗效。

Objective ： To investigate the effects of Jiawei Huangqi Guizhi Wuwu Decoction on prevention of hand - foot syndrome caused by xeloda. Methods： 53 patients were divided randomly into the treatement group and the control group. The treatement group takes chemotherapy plus Jiawei Huangqi Guizhi Wuwu Decoction, one dose everyday. The control group takes chemotherapy alone. Results ： 34.5% of patients suffered from hand - foot syndrome in treatment group and 58.3% in control group, 2 groups of comparisons differences have signigicance （ P 〈 0. 05 ）. Conclusion ： Jiawei Huangqi Guizhi Wuwu Decoction could prevent and treat hand - foot syndrome caused by xeloda.