小儿肾病患者治疗前后血清IL-6、TNF-α和VEGF检测的临床意义

Clinical Significance of Determination of Changes of Serum IL-6, TNF-α and VEGF Levels After Treatment in Pediatric Patients with Nephrotic Syndrome

目的:探讨了小儿肾病患者治疗前后血清IL-6、TNF-α和VEGF水平的变化及意义。方法:分别应用放射免疫分析和酶联双抗体夹心法测定了34例小儿肾病患者血清IL-6、TNF-α和VEGF的含量,并与30名正常健康儿童作比较。结果:小儿肾病患者在治疗前血清IL-6、TNF-α和VEGF水平均非常显著地高于正常儿童组(P<0.01),经治疗2个月后与正常儿童组比较仍有显著性差异(P<0.05)。结论:小儿肾病的发生、发展与血清IL-6、TNF-α和VEGF水平密切相关。

Objective To investigate the clinical significance of changes of serum IL - 6, TNF -α and VEGF levels after treatment in pediatric patients with nephrotic syndrome. Methods Serum IL -6, TNF -α （with RIA）, VEGF （with ELISA） levels were determined in 34 pediatric patients with nephrotic syndrome both before and after treatment as well as in 30 controls. Results Before treatment the serum IL- 6, TNF-α and VEGF levels in the patients were significantly higher than those in the controls （P 〈 0.01 ）. After 2 months of treatment, the levels dropped considerably but still remained significantly higher （P 〈 0.05）. Conclusion Development of nephrotic syndrome in pediatric patients was closely related to the serum IL - 6, TNF -α and VEGF levels.