尖锐湿疣患者治疗前后血清IL-2、IL-6、TNF-α和外周血B细胞、T淋巴细胞亚群检测的临床意义

Clinical Significance of Measurement of Changes of Serum IL-2,IL-6,TNF-α Levels Peripheral B Lymphocyte Count and T Subsets Distribution Type After Treatment in Patients with Condyloma Acuminatum

目的:探讨了尖锐湿疣患者治疗前后血清IL-2、IL-6、TNF-α和外周血B细胞、T淋巴细胞亚群水平及临床意义。方法:分别应用放免法、酶联法和单克隆抗体法对42例尖锐湿疣患者进行了血清IL-2、IL-6、TNF-α和外周血B细胞、T淋巴细胞亚群水平测定,并与30名正常健康人作比较。结果:尖锐湿疣患者在治疗前血清TNF-α水平和B细胞数均非常显著地高于正常人组(P<0.01),而IL-2、IL-6、CD3、CD4、CD4/CD8比值则显著地低于正常人组(P<0.01),经治疗后6个月,与正常人比较仍有显著性差异(P<0.05)。结论:尖锐湿疣是一种自身免疫调节失常的性传播疾病。

Objective To study the changes of serum IL - 2, IL - 6, TNF -α levels, peripheral B lymphocyte count and T subsets after treatment in patients with condyloma acuminatum. Methods Serum IL-2, TNF -α （with RIA） IL-6 （with ELISA） and B, T lympbocytes count in peripheral blood as well as T subsets distribution type （with monoclonal techniue） were examined both before and after treatment in 42 patients with condyloma acuminatum and 30 controls. Results Before treatment serum TNF -α levels and B lymphocytes count were significantly higher in the patients than those in controls （P 〈0.01 ）, while the serum IL-2, IL-6, CD3, CIM, CIM/CD8 levels were significantly lower （P 〈 0.01 ）, six months after treatment the levels had been markedly corrected but remain significantly different from those in controls （ P 〈 0.05 ）. Conclusion There were abnormal immuno regulations in patients with condyloma acuminatum.