血清SA、CEA、CRP在诊断结直肠癌患者的临床意义

Clinical Significance of Determination of Serum SA, CEA and CRP Levels in Patients with Colo-Rectal Cancer

目的：探讨血清唾液酸（SA）、癌胚抗原（CEA）和C反应蛋白（CRP）在诊断结直肠癌患者的临床意义.方法：测定120例结直肠癌患者血清SA、CEA、CRP浓度,并与肿瘤病理分期、分化程度及肿瘤复发等因素进行相关分析.结果：①血清SA、CEA、CRP浓度在结直肠癌Duke＇s临床分期中,存在显著性差异（P＜0.01）,升高程度为Duke＇s分期D＞C＞B＞A;②不同分化程度的肿瘤血清SA、CEA、CRP浓度变化存在显著性差异（P＜0.01）,分化程度越高,SA、CRP水平越低,CEA越高;③68例行根治手术后随访（1～5） 年复发29例,复发组血清SA、CEA、CRP浓度比未复发组显著升高（P＜0.01）.结论：SA、CEA和CRP可作为肿瘤临床分期的补充及手术方式选择的参考依据,并可作为判断术后复发的重要指标.

Objective To investigate the clinical usefulness of determination of serum SA, CEA and CRP levels in patients with colo -rectal cancer. Mothods Serum SA （with colorinetry）, CEA （with CLIA） and CRP （with ILIA） levels were measured in 120 patients with colo -rectal cancer. Results ① Serum SA, CEA and CRP levels increased significantly as the disease stage advanced from Duke A through Duke D. ② As the malignancy of the growth advanced from well - differentated to anaplastic, the serum SA and CRP levels increased significantly while the reverse was true for serum CEA levels. ③In 68 post - operative patients followed 1 ～ 5 years, the serum levels of SA, CEA and CRP were significantly higher in the patients with recurrence （ m = 29） than those in patients without recurrence （ n = 39） （P 〈 0.01 ）. Conclusion Serum SA, CEA and CRP levels were closely related to the disease process in patients with colo -rectal cancer.