脓毒症患者血清PCT与IL-6的变化

Changes of Serum Procalcitonin (PCT) and IL-6 Levels in Patients with Sepsis

目的:探讨前降钙素原(PCT)及白细胞介素6(IL-6)与脓毒症在感染性疾病中的诊断、治疗、病情评价作用。方法:应用双抗体夹心免疫发光法及双抗体夹心酶联免疫吸附法分别测定130例健康人和130例脓毒症患者急性期及恢复期血清PCT和IL-6含量。结果:PCT和IL-6水平在脓毒症患者组显著高于正常对照组,急性期显著高于恢复期,死亡组大于存活组。结论:PCT和IL-6在脓毒症发病机理中起重要作用,对早期诊断及判断预后有重要意义。

Objective To investigate the importance of determination of changes of serum proealeitonin （PCT） and IL - 6 levels in patients with sepsis. Methods Serum PCT （ with double - sandwich immunoflurosence assay） and IL - 6 （ with ELISA） levels were measured repeatedly in 130 patients with sepsis on d1, d3, d5, d7 after admission, Values in 130 healthy individuals were also measured as control. Results The serum levels of PCT and IL - 6 in the patients with sepsis of admission were significantly higher than those in controls, The levels dropped markedly in the survivors by d7, Among the septic patients, the levels in the succumbed patients were significantly higher those in the survivors （P 〈 0, 05 ）. Conclusion Serum PCT and IL - 6 values appeared to be of prognostic value in patients with sepsis.