摘要
Objective To study the effect of fluvastatin on changes of serum C-reactive protein(CRP) and soluable intercellular adhesion molecule-1(sICAM-1),soluabe vas-cular cell adhesion molecule-1(sVCAM-1) contents in patients with acute coronary syndrome(ACS). Methods 109 patients with ACS were randomly divided into fluvastatin-treated group(55 cases) and conventional therapy group (54 cases). The contents of serum CRP (with immunoturbidity method), sICAM-1,sVCAM-1 (with ELISA) were measured both before and after treatment for 8 weeks with fluvastat in in these cardiac patients as well as in 50 controls. Results ① Befor treatment, the levels of serum CRP, sICAM-1, sVCAM-1 were significantly higher in the patients with ACS than controls(P<0.01). ②After treatment,the levels of serum CRP, sICAM-1,sVCAM-1 in patients with fluvastatin decreased significantly(P<0.01), but the levels were not much changed in the conventional therapy group. Conclusion Fluvastatin can decrease inflammation and cell adhesion in patients with ACS .
Objective To study the effect of fluvastatin on changes of serum C - reactive protein（CRP） and soluable intercellular adhesion molecule - 1 （ sICAM - 1 ）, soluabe vas - cular cell adhesion molecule - 1 （ sVCAM - 1 ） contents in patients with acute coronary syndrome（ACS）. Methods 109 patients with ACS were randomly divided into fluvastatin - treated group（55 cases） and conventional therapy group （54 cases ）. The contents of serum CRP （ with immunoturbidity method）, sICAM - 1, sVCAM - 1 （with ELISA） were measured both before and after treatment for 8 weeks with fluvastat in in these cardiac patients as well as in 50 controls. Results ① Befor treatment, the levels of serum CRP, sICAM - 1, sVCAM - 1 were significantly higher in the patients with ACS than controls（P 〈0.01 ）. ②After treatment,the levels of serum CRP, sICAM - 1 ,sVCAM - 1 in patients with fluvastatin decreased significantly（P 〈0.01）, but the levels were not much changed in the conventional therapy group. Conclusion Fluvastatin can decrease inflammation and cell adhesion in patients with ACS .
出处
《放射免疫学杂志》
CAS
2007年第3期280-281,共2页
Journal of Radioimmanology
基金
连云港市125工程医学重点人才资助项目
