酮洛芬不同透皮制剂的体外透皮性和释放性

Permeation and in vitro Release of Different Ketoprofen Transdermal Preparations

分别制备含1%、3%、5%酮洛芬的混合型巴布剂、交联型巴布剂、透皮贴剂,以同浓度的酮洛芬凝胶剂作为对照组,采用改良Franz透皮扩散池,以离体小鼠皮肤为透皮屏障,考察酮洛芬在不同制剂中的体外透皮和释放性能。结果表明,同浓度酮洛芬在不同受试制剂的透皮速率依序为交联型巴布剂>混合型巴布剂>凝胶剂>透皮贴剂;3%酮洛芬在不同贴膏剂中的释放速率依序为混合型巴布剂>交联型巴布剂>透皮贴剂。

Mixed type cataplasm, crossed type cataplasm and transdermal patch containing 1%, 3 % and 5 % ketoprofen were prepared respectively. The permeation and in vitro release of the drug from four preparations were investigated using excised mouse skin as percutaneous permeation barrier with the same concentration ketoprofen gel as control group. The results showed that the order of permeation rate of the four preparations was crossed type cataplasm〉mixed type cataplasm〉gel〉transdermal patch; while the order of release rate of 3 % ketoprofen preparations was mixed type cataplasm〉crossed type cataplasm〉transdermal patch.