银杏内酯PELGE纳米粒的制备及理化性质

Preparation and Physicochemical Properties of Ginkgolide PELGE Nanoparticles

采用共沉淀法制备银杏内酯PELGE纳米粒,正交试验设计优化处方,并考察了优化制品的外观和体外释放行为。结果表明,所得纳米粒外观圆整,包封率为(66.9±1.7)%,粒径为(123.3±44.0)nm,体外24h累积释放率为60.2%。

The orthogonal design was used to optimize the formulation of ginkgolide nanoparticles by coprecipitation method using poly [monomethoxy ethylene glycol-b-（DL-lactic acid-co-glycolic acid）-b-monomethoxy ethylene glycol] （PELGE） as material. The appearance and in vitro release of the optimized products were investigated. The results showed that the products were spherical with the mean diameter of （123.3±44.0）nm and the mean entrapment efficiency of （66.9±1.7） %. The 24h accumulative release was 60.2 %.