西酞普兰与氟西汀治疗抑郁症的药物经济学分析

Pharmacoeconomic Analysis of Citalopram and Fluoxetine in Treatment of Depressive Disorder

目的:比较西酞普兰与氟西汀治疗抑郁症的成本与效果。方法:40例抑郁症患者随机分为A、B组,分别给予西酞普兰、氟西汀治疗6wk,应用药物经济学最小成本分析方法进行评价。结果:A、B组总有效率均为80%,成本分别为736·16、743·09元,成本-效果比分别为920·20、928·86。结论:西酞普兰为较佳方案。

OBJECTIVE： To compare the cost- effectiveness of citalopram and fluxetine in treatment of depressive disorder.METHODS： 40 cases of patients with depression were randomized into Group A and Group B, to be treated for 6wk respectively with citalopram and fluoxetine .A cost- minimization analysis in pharmacoeconomics was then conducted .RESULTS： The total effective rate of Group A and Group B was both 80%, against respective medication costs of 736.16 yuan and 74：3.09 yuan.The cost- effectiveness ratios were respectively 920.20 and 928.86.CONCLUSIONS： Citalopram is more costeffective in treatment of depression.