老年期抑郁症患者血清褪黑激素浓度及临床意义

Determination and clinical significance of serum melatonin levels in senile depressive patients

目的探讨抑郁症患者与血清褪黑激素（MT）浓度的关系。方法采用放射免疫法对57例老年期抑郁症患者和35例正常老年人的血清褪黑激素浓度进行测定。结果老年期不伴Ⅱ型糖尿病抑郁症患者组的血清褪黑激素浓度[（0．20±0．08）nmol／L]和伴Ⅱ型糖尿病抑郁症患者组的血清褪黑激素浓度[（O．25±0．07）nmol／L]均显著高于正常老年人[（0．15±0．05）nmol／L]（P〈0．05），18例老年期不伴Ⅱ型糖尿病抑郁症患者治疗前后血清褪黑激素浓度[（0．20±0．06）nmol／L和（0．22±0．07）nmol／L]差异无显著性（P〉0．05）；老年期抑郁症患者的HAMD评分与血清褪黑激素浓度无显著相关性（t=-0．133，P〉0．05）。结论高褪黑激素分泌很可能是老年抑郁症的一个特征性生物学指标。

Objective To explore the relationship between the serum melatonin level and depression. Methods Using radioimmunoassay ,the serum melatonin levels were determined in 57 senile depressive patients and 35 healthy controls. Results Before the treatment, compared with the control,the serum melatonin levels were significantly higher in both senile depressive group without type Ⅱ diabetes mellitus and senile depressive group with type Ⅱ diabetes mellitus, and the serum melatonin levels in senile depressive group with type Ⅱ diabetes mellitus were also significantly higher than those in senile depressive group without type Ⅱ diabetes mellitus. After the treatment, the change of the serum melatonin showed no significant difference in 18 depressive patients without type Ⅱ diabetes mellitus. The serum melatonin levels had no significant correlation with the total scores of Hamilton Depression Scale in depressive patients. Conclusion The high serum melatonin level may be a kind of typical biologic, index in senile depression.