混配农药对施药人员神经行为功能的影响

Effects of mixed pesticides on the neurobehaviorai functions in pesticide users

目的探讨混配农药施药人员神经行为功能的影响及意义。方法将正在使用混配农药且出现症状但胆碱脂酶活力〉70％者作为研究对象，应用世界卫生组织推荐的神经行为功能测试组合及症状自评量表（SCL-90），测试其神经行为功能。结果与对照组比较，农药组接触混配农药后各症状的发生率均显著高于对照组（P〈0．01）；心理状态剖面（POMS）问卷测试表明，农药组在T[（12．45±4．66）分]、D[（18．46±7．91）分]、F[（12．25±5．16）分]和C[（10．96±5．27）分]等的情感得分显著高于对照组（P〈0．01），在V分上显著低于对照组（P〈0．01），在A分上无显著差异；农药组数字译码、目标追踪及手工敏捷度得分，平均反应时显著低于对照组（P〈0．01）；且目标追踪错次也明显高于对照组（P〈0．01）；SCL-90测试结果表明，农药组在9组症候群因子均值、因子总分、因子总均分、阳性项目数等方面均显著高于对照组（P〈0．01）。结论混配农药可能造成接触者神经行为功能的改变，及时注意到这种变化，可预防混配农药中毒的发生。

Objective To explore the effects of mixed pesticides on human body and its meaning. Methods The users of mixed pesticides who had some signs but the activity of ChE beyond 70% were as subjects （pesticide group）. The neurobehavioral functions were tested with WHO neurobehavioral core test battery （WHO/ NCTB） and symptom check list-90 （SCL-90）. Results Compared with control group, the prevalence of each symptom increased significantly in mixed pesticide users, and each factor of WHO/NCTB and SCL-90 had obviously abnormal changes in mixed pesticide users（ P〈 0.01 ）. Conclusion The changes of neurobehavioral functions must be earlier than the changes of conductive function of the peripheral nerve in the users of mixed pesticides, which maybe provide the evaluating data for the early prevention of mixed pesticides poisoning.