AIDS相关症状对艾滋病患者生存质量的影响

THE INFLUENCE OF AIDS RELATED SYMPTOMS ON THE QUALITY OF LIFE FOR 64 PATIENTS LIVING WITH AIDS

[目的]探讨AIDS相关症状对艾滋病患者生存质量的影响。[方法]采用多阶段抽样方法,利用生存质量量表(WHOQOL-120HIV)对河南省驻马店市上蔡县64名艾滋病患者的生存质量进行评价和分析。[结果]64名艾滋病患者最常见的症状依次是虚弱或乏力(89.1%)、肌肉酸痛和注意力不集中(73.4%)、发热(64.1%)、焦虑或害怕(60.9%)和沮丧(54.7%)。出现不同数目(1￣2、3￣5、≥6)AIDS相关症状组的生存质量各个领域得分差异均具有统计学意义(P﹤0.001)。3组得分依次为生理领域:14.8±3.0、11.5±2.1、9.5±1.9(F=21.06,P=0.001);心理领域得分依次为14.5±1.9、12.1±1.4、10.9±2.0(F=12.50,P=0.001);独立水平领域得分依次为14.5±1.9、11.6±1.8、9.7±2.1(F=19.71,P=0.001);社会关系领域得分依次为:15.4±1.4、13.4±1.6、12.4±2.3(F=7.09,P=0.002);环境领域得分依次为:14.4±1.5、12.0±1.3、11.7±1.5(F=10.11,P=0.001);精神/宗教信仰领域得分依次为12.9±2.4、10.8±2.0、9.6±2.5(F=6.07,P=0.004)。Spearman等级相关分析显示,艾滋病相关症状数目与生存质量得分呈负相关(rs=-0.54,P=0.001),随着艾滋病相关症状数目增多,总生存质量得分降低。[结论]AIDS相关症状的数目与艾滋病患者总生存质量呈负相关,医务工作者在治疗疾病的过程中,必须加以重视,以提高患者的生存质量。

[Objoctivo] To explore the influence of AIDS related symptoms on the quality of life among patients living with AIDS. [MolhOdS] Multi-stage sampling was performed to obtain 64 patients living with AIDS in Zhumadian city, China. WHOQOL-120 HIV instrument was applied to evaluate the quality of life of the patients with AIDS. [ Iqosul＇ts] Symptoms of the patients with the highest frequency were weakness or hypodynamia （89.1%）, myalgia （73.4%）, fever （64.1%）, anxiety or fear （60.9%） and depression （71.0% ） .The scores of quality of life were significantly different between groups categorized by the number of AIDS related symptoms （P=0.001） . In the three groups （ 1-2, 3-5, ≥6）, the scores of Physical Domain were 14.8±3.0, 11.5±2.1 and 9.5±1.9 respectively （F = 21.06, P = 0.001） . The scores of Psychological Domain were 14.5 ± 1.9, 12.1 ± 1.4 and 10.9 ± 2.0 respectively （F = 12.50, P = 0.001） . The scores of level of Independence Domain were 14.5± 1.9, 11.6 ± 1.8 and 9.7 ± 2,1 respectively （F = 19.71, P = 0.001） . The scores of Social Relation Domain were 15.4 ±1.4, 13.4 ± 1.6 and 12.4 ±2.3 respectively （F = 7.09, P = 0.002） . The scores of Environmental Domain were 14.4 ± 1.5, 12.0 ±1.3 and 11.7±1.5 respectively （F = 10.11, P = 0.001） . The scores of Spirituality/Religion/Personal Belief Domain were 12.9 ± 2.4, 10.8 ± 2.0 and 9.6± 2.5 respectively （F = 6.07, P = 0.004） . Spearman correlation analysis shown that there was a negative correlation between total score of QOL and numbers of symptom in AIDS patients （r5 = -0.54, P = 0.001） . Patients with more AIDS related symptoms reported lower scores of quality of life. [ Conclusion] Symptoms have a negative impact on the quality of life. To improve the quality of life of patients, doctors should pay more attention to the relationship between AIDS related symptoms and the quality of life for patients, to improve their quality of life.