激光心肌血管重建加心脏网膜固定术治疗缺血性心脏病的实验研究

AN EXPERMENTAL STUDY OF MYOCARDIAL REVASCULARIZATION IN THE TREATMENT OF ISCHEMIC HEART DISEASE

２６条杂交犬分为３组：对照组（ｎ＝１０）、激光心肌血管重建术组（ｎ＝８）和激光心肌血管重建＋心脏网膜固定术组（ｎ＝８）。分别监测了ＥＫＧ（ＳＴ—Ｔ）、心输出量、放射性同位素８６Ｒｂ摄取分数和组织学检查等，结果显示激光打孔后ＳＴ—Ｔ改变恢复、心输出量增加、心肌血供增加，以激光心肌血管重建术＋心脏网膜固定术组最好。激光孔道以及新生的血管和形成的网膜－心肌侧支循环，都能为缺血心肌提供血液和改善心功能。

Twenty six mongrel dogs were divided into control group (C group,n=10),Laser myocardial revascularization (LMR) group (L group,n=8) and Laser myocardial revascularization+cardio omentopexy group (O group,n=8).They were monitored by EKG and NCCOM3 for ST-T and cardial output (CO).Fractional 86 Rb uptake and biopsy were obtained. Our results revealed that the change of ST-T segment recovered instantly and the CO increased after LMR. The channels of LMR remained patent and communocated with ventricular cavity for 2 weeks, and then closed by clot and fibrosis.But it′s interesting to find many newborn vessels and some of them like to form artery. The blood flow in the ischemic myocardium may improve by the channels of LMR,the newborn vessels and the lateral circulation between the ischemic region and grafted omentum strip.