1，6-二磷酸果糖联合复方丹参治疗新生儿窒息后心肌损害

Effect of fructose-1,6-diphosphate combined with Fufang Danshen injection on myocardial damage due to neonatal asphyxia

目的 探讨1．6-二磷酸果糖联合复方丹参注射液治疗新生儿窒息后心肌损害的疗效。方法 72例新生儿窒息后心肌损害患儿分为治疗组（n=35）和对照组（n=37）．两组均给予支持对症治疗，在此基础上．治疗组给予1,6-二磷酸果糖和复方丹参注射液，7d为1个疗程；观察患儿治疗过程中症状、体征、心电图、心肌酶谱的变化情况。结果 治疗组的总有效率（91．4％）明显高于对照组（81．1％）。治疗组于疗程结束后各项心肌酶谱的改善情况均优于对照组，差异有统计学意义（P〈0.05）。结论 1，6-二磷酸果糖联合复方丹参注射液治疗新生儿窒息后缺氧缺血性心肌损害效果好。

Objective To investigate the effect of fructose-1,6-diphosphate（FDP） plus Fufang Danshen injection on treating myocardial damage due to neonatal asphyxia. Methods 72 children with myocardial damage due to neonatal asphyxia were divided into treatment group（ n = 35） and control group（ n = 37）. All the children were treated according to the symptoms, besides those in the treatment group were administrated with FDP and Fufang Danshen injection intravenously,and 7 days as a course. The changes of symptoms, physical signs, electrocardiogram （ECG） and creatine kinase were observed during the treatment. Results The total effective rate was obviously higher in the treatment group（91.4 % ） than in the control group（81.1% ）. The ameliorations of creatine kinase after treatment in the treatment group were all superior to those in the control group（P 〈 0.05）. Conclusion FDP plus Fufang Danshen injection has better effects on the hypoxic ischemic myocardial damage due to neonatal asphyxia.