利多卡因联合多巴胺治疗新生儿缺氧缺血性脑病

Effect of lidocaine and dopamine intervention therapy to the neonate hypoxic ischemic encephalopathy

目的 探讨多巴胺与利多卡因联合对新生儿缺血缺氧性脑病（HIE）的治疗作用及预后改善的临床意义。方法 将2004年6月至2006年10月我院收住的足月中、重度HIE患儿，随机分为治疗组和对照组各45例，对照组采用常规治疗，治疗组在常规治疗的基础上加用利多卡因和多巴胺，治疗期间严密观察患儿神经系统症状和体征，并进行神经行为评分，比较两组病例的近期治疗效果。结果 对照组惊厥发生40例（89％）、惊厥持续（8．79±6．84）d、住院时间（14．36±6．67）d、预后不良率34％，均较治疗组为差，两组的总有效率分别为66．7％和91．1％，差异有统计学意义（P〈0．01）。结论 多巴胺与利多卡因联合对新生儿中、重度HIE有一定的协同治疗作用，尤其对患儿症状控制及预后改善有明显效果。

Objective To study the role of lidocaine and dopamine intervention therapy and the significance on amelioration prognosis judgments to the neonate hypoxic ischemic encephalopathy（HIE）. Methods 90 patients were randomly divided into two groups with HIE at our hospital during the years from 2004 to 2006. Group Ⅰ were treated with routine medicine, group Ⅱ were treated with lidocaine and dopamine ,the reactions following treatment were observed. Results There were significant difference in the convulsion incidence, convulsion result time, time to be in hospital and clinical prognosis between the two groups. The total efficiency in two groups were 66.7 % and 91.1% （P〈 0.01）. Conclusion Lidocaine and dopamine have cooperative action in treating HIE. It has phaneroresult to symptom and amelioration prognosis, which is worthing in HIE therapeutics.