CA153、CEA在乳腺癌中的表达及临床意义

Study on expression of CA153 ,CEA and its clinical significance in the patients with breast cancer

目的 探讨乳腺癌患者血清糖类抗原153（CA153）和癌胚抗原（CEA）表达及临床意义。方法 利用全自动快速粒子酶免疫分析系统，检测30例健康人、52例乳腺良性疾病和208例乳腺癌患者血清CA153和CEA的水平，分析CA153和CEA检测值与乳腺癌临床特征之间的关系。结果 乳腺癌患者治疗前血清CA153及CEA的水平明显高于治疗后的水平（P〈0.001），初诊初治及复发转移患者的血清CA153及CEA的水平明显高于乳腺良性病变和健康人群（P〈0．001）；联合检测可以提高对乳腺癌诊断的阳性率。结论 联合检测CA153及CEA水平可以提高对乳腺癌诊断的敏感性和准确性，并可用于该肿瘤的预后判断。

Objective To investigate the expression of carlbohrdyate antigen（CA153） and carcinoembryanic antigen（CEA） ,and its clinical significance in the patients with breast cancer. Methods The sera CA153 ,CEA levels were detennined by IMX in 30 healthy persons,52 patients with benign breast diseases and 208 patients with breast cancer from 1998 to 2002, the correlation between the CA153,CEA level and the clinical characleristics was also detected. Results In the patienls with breast cance, the level of serum CA153 and CEA was significantly higher in pretreatment than that in post-treatment（P 〈 0. 001 ）, and these both level of CA153 and CEA was also higher in the patients who were first visitors and had metastasis than that in the patients with benign breast diseases and healthy persons（P 〈 0. 001 ）, the positive rate in diagnosis breast cancer could be raised by combined test of serum CA153 and CEA. Conclusion The combination test of serum CA153 and CEA level can improve the diagnostic rate of breast cancer and can be used for prediction of prognosis.