羟基喜树碱联合化疗治疗中晚期消化道肿瘤的疗效观察

Efficacy of hydroxycamptothecin combined with chemotherapy in the treatment of advanced digestive tract cancers

目的:观察使用羟基喜树碱(HCPT)治疗中晚期消化道肿瘤的疗效与毒性。方法:中晚期消化道肿瘤患者119例,不同病种采用不同的化疗方案,每21d为1周期,4周期为1疗程评价疗效。结果:总有效率54.6%,其中胃癌尤为明显,有效率63.3%。主要不良反应为白细胞减少和胃肠道反应。结论:HCPT联合化疗治疗中晚期消化道肿瘤患者安全有效,与其他抗癌药无交叉耐药性。

Objective： To observe the efficacy and toxicity of hydroxycamptothecin（HCPT） in the treatment of advanced digestive tract tumors. Methods： Total of 119 patients with advanced digestive tract tumors were studied. According to their diseases, they were treated with hydroxycamptothecine plus different chemotherapy respectively for 4 cycles with interval of 21 days. Results： The total response rate was 54.6%, and the clinical response rate of patients with gastric cancer was 63.3% ,which was the highest among the study patients. The adverse effects consisted of leukocytopenia and gastrointestinal reactions. Conclusion： Hydroxycamptothecin combined with chemotherapy is effective and safe to patients with advanced digestive tract cancers, no cross drug resistance to other anticancer drugs.