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对氧磷酶2基因多态性与阿尔茨海默病的相关性研究 被引量：4

The association of paraoxonase 2 polymorphisms with Alzheimer's disease
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摘要 目的探讨对氧磷酶2(paraoxonase 2,PON2)基因多态性(148Ala/Gly;311Cys/Ser)与Alzheimer病(AD)之间的关系。方法用PCR-RFLP分析技术对132例AD患者和186例年龄匹配的健康对照者进行PON2 148Ala/Gly及311Cys/Ser基因多态性的分析。结果PON2基因14.8、311位点存在多态性,其基因型频率和等位基因频率在AD患者和正常对照者间差异无显著性。结论PON2基因多态性与AD未发现显著相关性。 Objective To investigate the relation between paraoxonase 2 （PON2） gene polymorphisms （148Ala/Gly and 311Cys/ Ser） and Alzheimer＇s disease （AD）. Methods 132 AD patients and 186 age-matched control health person were enrolled in this study for examination of PON2 polymorphisms using polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP）. Results The PON2 gene polymorphisms （148 Ala/Gly and 311 Cys/Ser） were demonstrated. The genotype frequencies and allele frequencies were not significantly different between AD group and control group. Conclusions Polymorphisms of PON2 gene are not significantly associated with AD.
作者 邬强 钱士匀
机构地区 中国热带农业科学院热带作物生物技术国家重点实验室中国热带农业科学院热带生物技术研究所 海南医学院检验医学系
出处 《中国老年学杂志》 CAS CSCD 北大核心 2007年第11期1038-1041,共4页 Chinese Journal of Gerontology
基金 海南省卫生厅科研项目(2005-61)
关键词 对氧磷酶2 遗传多态性 阿尔茨海默病 Paraoxonase 2 （PON2） Polymorphism Alzheimer＇s disease
分类号 R749.16 [医药卫生—神经病学与精神病学]
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参考文献12

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二级参考文献10

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共引文献14

同被引文献45

引证文献4

二级引证文献5

中国老年学杂志
2007年 第11期

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