肝细胞癌患者血清VEGF水平检测及与临床分期的相关分析

Detection of serum VEGF and their association analysis in hepatocellular carcinoma

目的检测肝细胞癌(HCC)患者血清血管内皮生长因子(VEGF)含量并分析与临床分期的相关性。方法用ELISA法检测30例健康对照者和146例HCC患者血清VEGF含量,分析VEGF对HCC的诊断价值和临床分期的关系。结果HCC组VEGF水平显著高于健康对照组VEGF水平(P<0.01)。HCC患者VEGF水平与肿瘤大小呈正相关(P<0.01),HCC术后转移和复发患者血清VEGF水平明照升高(P<0.05),TNMⅢ、Ⅳ期患者血清VECF水平也明显高于Ⅰ、Ⅱ期患者(P<0.01)。结论血清VEGF测定可作为诊断HCC和临床分期的重要指标。

Objective To detect concentration of serum vascular endothelial growth factor （VEGF）in hepatocellular carcinoma （HCC） and analyze their relation between VEGF and clinical stages. Methods By ELISA serum VEGF levels were determined in 146 patients with HCC and 30 healthy control. The relationship between VEGF and clinical stages were analyzed. Results The serum VEGF levels in HCC group were significantly higher than those in control group （P 〈0.01 ）. The levels of serum VEGF in the patients with HCC were strongly associated with tumor size （ P〈0. 01 ）. Serum VEGF showed a significant elevation in the patients with remote metastasis, recurrent HCC and TNM Ⅲ,Ⅳ stages （ P 〈 0.01 ）. Conclusions The detection of serum VEGF might provide a significant index marker for HCC diagnosis and clinical stages.