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东北满族1O个Y染色体短串联重复序列的多态性研究 被引量：2

Genetic Polymorphism of Y-chromosome Short Tandem Repeat in Chinese Man Ethnic Population
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摘要 目的调查满族Y染色体上10个短串联重复序列基因座及单体型的遗传多态性。方法采用PCR复合扩增和基因测序仪荧光检测方法，检测满族71例无关个体10个Y—STR位点的遗传多态性分布。结果在DYS392、DYS389I、DYS389II、DYS441、DYS442、DYS447、DYS460、DYS461、DYS463和DYS459等10个基因座中共检出59个等位基因，等位基因频率分布在0．0141～0．5915之间，基因多样性（GD）分布在0．6006（DYS459）～0．8384（DYS441）之间，等位基因多样性均大于0．6。由10个基因座组成的Y染色体单体型系统中单体型有70种，单体型多样性为0．9998。结论上述10个Y—STR所构成的单体型在满族群体中具有较高的多态性，可用于法医学个体识别和亲子鉴定、遗传学及人类学的相关研究。 Objective To investigate polymorphisms of ten Y-STR by using DNA samples OF 71 Man male individuals from Liaoning Province. Methods DYS392, DYS389Ⅰ, DYS389Ⅱ, DYS441, DYS442, DYS447, DYS460, DYS461, DYS4453 and DYS459 were amplified by multiplex PCR. Products were detected with an ABI PRISM 3130xl Genetic Analyzer. Results The allele diversity values for each locu were ranged from 0.600 6 （ DYS459 ） to 0.838 4 （ DYS441 ）. Gene diversities were higher than0.6. Furthermore 70 haplotypes from 10 Y-chromosome STRs loci were found in the sample and a high haplotyp diversity O. 999 8 was determined. Conclusion The ten Y chromosomal STR loci are highly polymorphic and can be applied in forensic cases and population genetics.
作者 郑立红 李士林 白静 陈峰 傅松滨
机构地区 哈尔滨医科大学医学遗传学研究室 复旦大学生命科学院遗传所
出处 《国际遗传学杂志》 CAS 2007年第3期165-168,共4页 International Journal of Genetics
关键词 Y染色体 短串联重复 遗传多态性 单体型 Y chromosome Short tandem repeats Genetic polymorphism Haplotype
分类号 D9 [政治法律—法学]
  • 相关文献

参考文献8

  • 1冯雪,徐平,李生斌.鄂伦春族Y染色体短串联重复序列多态性研究[J].中华医学遗传学杂志,2005,22(5):585-588. 被引量：6
  • 2Nei M. Molecular Evolutionary Genetics. New York: Columbia University Press. 1987.
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  • 8Chun BW, Shin SC, Kim YJ, et al. Allele frequencies and haplotypes of the STR loci of the PowerPlex Y-system in southern populations from Korea . Forensic Science International 2005,148 : 225-231 .

二级参考文献9

  • 1杨剑,刘雅诚,唐晖,霍振义.北京地区人群Y染色体STR遗传多态性[J].中国法医学杂志,2002,17(6):346-347. 被引量：10
  • 2Walsh PS, Metzger DA, Higuchi R. Chelex 100 as a medium for simple extraction of DNA for PCR based typing from forensic meterial. Biotechniques,1991,10:506-513.
  • 3Nei M. Molecular Evolutionary Genetics. New York: Columbia University Press,1987.
  • 4Tang JP, Hou YP, Li YB, et al. Characterization of eight Y-STR loci and haplotypes in a Chinese Han population. Int J Legal Med,2003,117:263-70.
  • 5Pepinski W, Niemcunowicz-Janica A, Skawronska M. Y-chromosome STR haplotypes in a population sample of the Byelorussian minority living in the northeastern Poland. Forensic Sci Int,2004,140:117-121.
  • 6Lee HY, Oh JE, Han GR, et al. Allele frequencies and haplotypes of six new Y-specific STR loci in Koreans. Forensic Sci Int,2003,136:89-91.
  • 7Yung JK, Dong JS, Jung MK. Y-chromosome STR haplotype profiling in the Korean population. Forensic Sci Int,2001,115:231-237.
  • 8卢岩,王保捷,丁梅,庞灏,孙大成.中国辽宁汉族DYS390、DYS389Ⅰ/Ⅱ基因座及单倍型研究[J].中国医科大学学报,2001,30(1):25-27. 被引量：2
  • 9赵东,王保捷,丁梅,卢岩,孙大成,刘志芳,李春梅.中国汉族及日本群体7个Y-STR位点及单倍型的遗传多态性和群体差异[J].法医学杂志,2003,19(3):143-148. 被引量：6

共引文献5

同被引文献13

  • 1Caglia A, Boschi I, Scamicci F, et al. High resolution analysis of male genomes by the addition of nine biallelic polymorphisms to the Classic 8-STR forensic haplotype. Inter Congr Ser, 2003, 1239: 307-310.
  • 2Hall A, Ballantyne J. Novel Y-STR typing strategies reveal the genetic profile of the semen donorin extended interval post-coital cervicovaginal samples. Forensic Sci Int , 2003, 136: 58-72.
  • 3Tang JP, Hou YP, Li YB, et al. Characterization of eight Y-STR loci and haplotypes in a Chinese Han population. Int J Legal Med, 2003,117:263-270.
  • 4Sibille I, Duvemeuil C, Lorin de la Grandmaison G, et al. Y-STR DNA amplification as biological evidence in sexually assaulted female victims with no cytological detection of spermatozoa. Forensic Sci Int , 2002,125: 212-216.
  • 5Nei M. Molecular Evolutionary Genetics, New York:Columbia University Press, 1987.
  • 6Chun BW, Shin SC, Kim Y J, et al. Allele frequencies and haplotypes of the STR loci of the powerPlex Y-system in southern populations from Korea. Forensic Sci Int, 2005, 148:225-231.
  • 7Wang XL, Sawaguchi T. Analysis of Y-STR Loci in a population sample from Northeast China. J Forensic Sci,2006,51:195-198.
  • 8侯一平,刘雅诚.法医学DNA分型:STR遗传标记的生物学、方法学及遗传学[M].2版.北京:科学出版社,2007:I.
  • 9Carracedo A, Beckmann A, Bengs A, et al. Results of a collaborative study of the EDNAP group regarding the reproducibility and robustness of the Y-chromosome STRsDYS19,DYS389 I and II , DYS390 and DYS393 in a PCR pentaplex format[J]. Forensic Sci Int, 2001,119 (1) :28-41.
  • 10Zhang Y, Lee J. Genetic of Y-chromosomal STR loci in South Korean population[J]. Forensic Sci Int, 2007, 173(2-3) : 225-300.

引证文献2

二级引证文献3

国际遗传学杂志
2007年 第3期

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