肺癌中Pten/MMAC1/Tep1蛋白的表达及临床意义

Expression and significance of Pten/MMCAI/Tep1 protein in lung adenocarcinoma and squamous cell carcinoma

目的:探讨抑癌基因Pten/MMAC1/Tep1蛋白在不同病理分期(pTNM)的肺腺癌、鳞癌中表达及其临床意义。方法:应用S-P免疫组织化学方法检验87例肺腺癌、鳞癌中Pten/MMAC1/Tep1蛋白表达,与其临床病理分期pTNM的关系。结果:肺腺癌组织中的Pten/MMAC1/Tep1蛋白表达阳性率为61.9%,肺鳞癌中表达阳性率为40.0%。二者Pten/MMAC1/Tep1蛋白表达均与肺癌的临床病理分期pTNM、分化程度有关(P<0.01),而与肿瘤的大小无关。结论:检验Pten/MMAC1/Tep1蛋白在肺癌中的表达可能对肺腺癌、鳞癌的疗效评估和预后评价具有一定意义。

Objective： To investigate the expression of Pten/MMAC1/Tep1 protein in lung adenocarcinoma and squamous cell carcinoma of different pathological stages （pTNM） and its clinical significance. Methods： The expression of Pten/MMAC1/Tep1 protein in 87 cases of lung adenocarcinoma and squamous cell carcinoma was detected by SP immunohistochemical method. The relationship between the expression of Pten/MMAC1/Tep1 protein and pTNM stages was analyzed statistically. Results： The positive expression rates of Pten/MMAC1/Tep1 protein were 61.9% in lung adenocarcinoma and 40.0% in lung squamous cell carcinoma. The expression of Pten/MMAC1/Tep1 protein in them was related to pTNM stages （ P 〈 0.01 ）, but was not associated with tumor size. Conclusion： It is valuable to detect the expression of Pten/MMAC1/Tep1 protein for evaluating the treatment and prognosis of lung adenocarcinoma and squamous cell carcinoma.