正常成人不同年龄段大脑白质纤维各向异性差异研究

Study of changes of the cerebral white matter anisotrapy in normal adult

目的:探讨正常成人不同年龄大脑白质纤维磁共振弥散张量各向异性的差异。方法:62名正常志愿者大脑白质纤维不同部位,包括外囊、内囊前肢、内囊后肢、胼胝体膝部和胼胝体压部的FA值和ADC值。结果:胼胝体膝部(F=3.113,P=0.024)和豆状核(F=3.229,P=0.020),在各年龄组之间FA值差异有显著性意义;内囊前肢(F=3.093,P=0.024)和豆状核(F=3.824,P=0.009),ADC值差异有显著性意义。FA值呈正相关的部位有内囊前肢(r=0.293,P=0.0349)、胼胝体膝部(r=0.322,P=0.0202),ADC值呈现正相关的部位只有外囊(r=0.365,P=0.00925)。结论:不同年龄段大脑白质纤维的FA值和ADC值是不同的,随着年龄增大,FA值呈现下降趋势,ADC值则有增高的趋势。

Objective：To investigate changes of the cerebral white matter anisotrapy during normal aging by using diffusion-tensor MR imaging. Methods-52 healthy adult volunteers（ 28 men,34 women; age range 20- 68 years; mean age 44.7years） were studied using MR diffusion tensor. The FA values and ADC values were measured. The ROIs were external capsule, anterior limb of the internal capsule, posterior limb of the internal capsule, genu of corpus callosum, splenium of corpus callosum,lentiform nucleus, caudate nucleus, thalamus and oerebrospinal fluid.Results：The significant difference of the FA valaes was found in the genu of corpus callosum（ P = 0.024）, anterior limb of the internal capsule（ P = 0.0349） with aging. Significant increase of ADC vlues was observed with aging in external capsule（ P = 0.00925）, anterior limb of the internal capsule（ P = 0.0349） and lentiform nucleus（ P = 0.009）. Conclusion： There was a tenuous FA value reduction and ADC value increase with aging.