HLA-DRB1，DQA1，DQB1基因单倍型与华东地区汉族人群白癜风的相关性

Association of HLA-DRB1,DQA1,DQB1 haplotypes with vitiligo in a Han population in East China

目的探讨HLA-DRB1、DQA1、DQB1基因单倍型与华东地区汉族人群白癜风的相关性。方法采用聚合酶链反应-序列特异性寡核苷酸探针（PCR—SSOP）方法检测华东地区汉族白癜风患者HLA—DRB1、DQA1、DQB1位点的等位基因，运用遗传学群体与家系资料计算机分析系统3．0筛选并分析单倍型。结果与正常人对照组比较，HLA-DRB1＊09-DQA1＊03-DQB1＊0303单倍型频率显著增高（n=0．02，OR=2．542）。结论在华东地区汉族人群中，HLA—DRB1＊09-DQA1＊03-DQB1＊0303单倍型可能是白癜风的易感单倍型。

Objective To investigate the association of HLA-DRB 1, DQA 1, DQB 1 haplotypes with vitiligo in a Han popultion in East China. Methods Ninety-eight patients with vitiligo and 150 healthy controls were studied for HLA-DRB1, DQA1 and DQB1 alleles by PCR- sequence specific oligonucleotide probes （SSOP） typing. Then, population and pedigree analysis programs （PPAP 3.0） was used to screen and analyze haplotypes. Results The fi＇equency of the haplotype HLA-DRB1＊09-DQA1＊03-DQB1＊0303 was significantly higher （ Pc = 0.02, OR = 2.542 ） in the vitiligo patients than in the controls. Conclusions Our results suggest that a correlation exists between HLA-DRB1, DQA1, DQB1 haplotypes and vitiligo, and HLA-DRB1＊09-DQA1＊03-DQB1＊0303 may be a susceptible haplotype for vitiligo in the Han population in East China.