化浊解毒活血方对子宫内膜异位症患者血浆孤啡肽及前列腺素的影响

Effect of Huazhuo Jiedu Huoxue Recipe on plasma orphanin FQ and prostaglandins in the patients of endometriosis with pain

目的:观察化浊解毒活血方(藿香、佩兰、半夏、陈皮、茯苓等)对子宫内膜异位症伴疼痛患者经期血浆孤啡肽及前列腺素水平的影响。方法:采用放射免疫法测定25例内异症无疼痛妇女(对照组)、31例内异症伴轻度疼痛妇女(轻度组)和29例内异症伴重度疼痛妇女(重度组)血浆孤啡肽、前列腺素的含量。对内异症疼痛组采用化浊解毒活血中药治疗,比较治疗前后血浆孤啡肽、前列腺素含量的变化。结果:内异症疼痛患者经期血浆OFQ、PGF2a、PGE2、6-酮-PGF1a、TXB2含量均显著高于无疼痛患者(P<0.05),6-酮-PGF1a/TXB2比值显著低于无疼痛患者(P<0.05);内异症重度疼痛组血浆OFQ、PGF2a、PGE2含量均明显高于轻度疼痛组(P<0.05)。内异症疼痛组经化浊解毒活血中药治疗后,OFQ、PGF2a、PGE2含量显著下降,6-酮-PGF1a水平显著升高(P<0.05)。结论:1、血浆孤啡肽及前列腺素水平均与子宫内膜异位症患者疼痛的发生、发展密切相关。2、化浊解毒活血中药治疗可使患者的OFQ、PGF2a、PGE2含量显著下降,而6-酮-PGF1a水平显著升高。

AIM： To evaluate the effect of Huazhuo Jiedu Huoxue Recipe （Herba Agastaches, Herba Eupatorii, Rhizoma Pinelliae, Pericarpium Citri reticulatae, Poria, etc. ） on plasma orphanin FQ （OFQ） and prostaglandins in the patients of endometriosis （EM） with pain. METHODS ： The concentrations of plasma OFQ and prostaglandins were measured by radioimmunoassay before and after the treatment on the patients of EM with pain. 29 patients of EM with severe pain （severe group）, 31 patients with slight pain（ slight group） and 25 patients without pain （control group） were studied. RESULTS： The levels of OFQ. PGF2a. PGE2. 6-keto-PGF1a and TXB2 in plasma were significantly higher in patients of EM with pain than that of patients without pain （ P 〈 0.05 ）, while the ratio of 6-keto-PGF1a versus TXB2 was much lower in that of patients with pain （P 〈 0.05 ）. The plasma OFQ. PGF2a and PGE2 in severe group was significantly higher than the slight group （ P 〈 0.05 ）. Plasma OFQ. PGF2a and PGE2 contents were significantly decreased, and plasma 6-keto-PGF1a level was markably increased after the treatment with Huazhuo Jiedu Huoxue Recipe （P 〈 0.05 ）. CONCLUSIONS ： 1. Pain is associated with OFQ and prostaglandins in patients of endometriosis with pain. 2. Huazhuo Jiedu Huoxue Recipe can make plasma OFQ. PGF2a and PGE2 contents significantly decrease, and 6-keto-PGF1a level markably increase.