氨甲基吡嗪的制备新方法

A New Method for Preparation of Aminomethylpyrazine

目的:以氰基吡嗪为原料制备氨甲基吡嗪。方法:用红铝作为还原剂还原氰基吡嗪制备氨甲基吡嗪。结果:得到了较优的反应条件:氰基吡嗪与红铝的摩尔量配比为1∶2,反应温度为0℃,反应时间为2小时。氨甲基吡嗪的收率为38%,反应条件温和。结论:本方法操作简便,还原程度可控,后处理方便。

Objective： To study the synthesis of aminomethylpyrazine starting from cyanopyrazine. Methods：Aminomethylpyrazine was prepared via reduction of cyanopyrazine by using red-Al （Trade Name： Ester,^TM solution ,70% red-Al in toluene） as reducing agent. Results：The better reaction conditions were optimized as follows： the mole ratio of cyanopyrazine to red-Al was 1：2, and the reaction temperature was 0℃, the yield of aminomethylpyrazine was 38 %. The reaction was carried out under moderate conditions. Conclusion：The process is easily handled and the degree of reduction can be controlled.