慢性阻塞性肺病几项免疫学指标的测定及临床意义

Immunological Markers in Patients with COPD and Their Clinical Significance

对慢性阻塞性肺病(COPD)发作期患者40例,缓解期35例进行外周血淋巴细胞(PBL)亚群、免疫球蛋白、溶菌酶及粒细胞集落刺激因子(G-CSF)测定。结果显示:1.急性发作期与正常对照组相比PBL亚群CD_3^+、CD_4^+、CD_4^+/CD_8^+明显下降;CD_8^+、CD_(20)^+明显增高。中性粒细胞吞噬率(％)、加号积分值均降低(P<0.01)。血清免疫球蛋白(IgG,IgA)水平降低(P<0.01),G-CSF阳性率升高。2.缓解期各项免疫指标虽有好转,但与正常组相比,仍有显著性差异(P<0.01,<0.05)。研究表明COPD的发病和转归与机体免疫机能低下密切相关。

Cellular and humoral immunologicai parameters were determined in 75 patients with chronic obstructive pulmonary disease(COPD)incIuding 40 in exacerbation stage and 35 in remission stage. The results showed that while the cases were in exacerbation stage, CD3+, CD4+ levels and CD4+/CD8+ ratio decreased remarkably (P<0. 01),serum IgG,IgA levels decreased significantly(P<0. 01). The phagocytosis percentage of peripheral polymorphonuclear and the integral value of the plus sign reduced (P< 0. 01);G-CSF positive rate was higher, comparing with normal control groups. For the cases in remission stage, all immunologicai parameters investigated were improved, but remarkable differences were observed between COPD patients with remission and healthy subjects. It was demonstrated that the relationship between the decrease of immunologic function and outcome of COPD existed.