头孢泊肟酯颗粒中主药溶出度的测定

Determination of the Dissolution of the Chief Agent from Cefpodoxime Proxetil Granules

目的:建立测定头孢泊肟酯颗粒中主药溶出度的方法。方法:采用紫外分光光度法,在264nm波长处测定头孢泊肟酯颗粒中主药的吸收度,并计算回收率和溶出度。结果:头孢泊肟酯检测浓度线性范围为1.4～20μg.mL-1(r=0.9999);平均回收率为99.5%(RSD=0.5%);3批样品的30min溶出度均在90%以上。结论:本方法准确、可靠,可用于该制剂的溶出度测定。

OBJECTIVE： To determine the dissolution of the chief agent from cefpodoxime proxetil granules. METHODS： The absorbability of cefpodoxime proxetil granules was determined by UV spectrophotometry with detection wavelength set at 264nm; and the recovery and dissolution were computed. RESULTS： The linear range of cefpodoxime proxetil was 1.4- 20μg · mL^-1（ r = 0.999 9）, with the average recovery rate at 99.5% （RSD = 0.5% ） .The dissolutions of three batches of samples were all above 90% at 30rain. CONCLUSION： The method is accurate and reliable, and applicable for the determination of the dissolution of the chief agent from cefpodoxime proxetil granules.