谷氨酸与慢性疼痛

Glutamate and Chronic Pain

参与慢性疼痛形成与发展的神经递质有许多,其中兴奋性氨基酸(主要是谷氨酸)是介导伤害性信息初级传入的重要神经递质,是诱发慢性疼痛形成和持续的重要因素.伤害性刺激直接或间接地引起传入神经末梢(Aδ纤维和C纤维)释放谷氨酸(Glu)等神经递质,Glu与脊髓背角的N-甲基-D-天门冬氨酸(NMDA)受体和非NMDA受体结合,引起脊髓背角神经元兴奋阈值降低、兴奋性增高(即发生了中枢敏感化)是慢性疼痛形成的重要起始因素.

There are many neurotransmissions participating in the formation and development of chronic pain. Among them excitatory amino acids （mainly glutamate） is one of important neurotransmissions to transmit primary information of nociperception and is a significant factor to induce the formation and duration of chronic pain. Nocuous stimulation directly or indirectly lead to the primary afferents ending release such as glutamate （Glu）. Binding to N -methyl-D-asparate （NMDA） and non-NMDA receptors, Glu initiates the decline of exciting threshold and increase of excitability of the neuron in dorsal horn of spinal cord, which is the central sen-sitization that the major origin factors of chronic pain.