肝纤维化的治疗进展

Progress of Research on Treatment of Liver Fibrosis

肝纤维化是由于细胞外基质(ECM)的合成大于降解导致过度沉积,是纤维增生与纤维分解不平衡而引起的病理过程.是各种慢性肝病发展的必经阶段,由于多种致病因素引起肝脏的损伤和炎症所共有的病理特征,也是向肝硬化等进一步发展、恶化的重要中间环节.当今大量研究发现,肝纤维化是一个可逆的过程,早期诊断与及时给予有效治疗可减缓或防止发展成为肝硬化.现就肝纤维化的治疗研究现状作一简要综述.

Objective Liver fibrosis is a pathologic process that leads to deposition of an excess of extra cellular matrix （ECM）, which is due to the synthesis of ECM exceeding the degradation of ECM. The balance between synthesis and degradation of fiber has been broken. Multiple etiological factors cause injury and inflam-mation of liver. Liver fibrosis is a common character in most kinds of chronic liver disease, which induce hepatic cirrhosis. Today, a lot of studies indicated that liver fibrosis was reversible and it was very important to find ways to block or slow down the paces of hepatic cirrhosis through early diagnosis and effective treatment in time. The article reviews the current state of treatment on liver fibrosis.