培哚普利与倍他乐克联用治疗慢性充血性心力衰竭的疗效观察

Influence of acertil combined with betaloc on the cardiac function in patients with congestive heart failure

目的:观察雅施达和倍他乐克联合治疗对慢性充血性心力衰竭(CHF)病人的心功能、心率、血压、心胸比率及左室射血分数(LVEF)的影响。方法:75例CHF病人随机分为两组,治疗组36例采用倍他乐克、雅施达、地高辛、利尿剂治疗;对照组39例采用地高辛、利尿剂、扩血管药治疗,均治疗12周。结果:治疗组心率减慢,血压下降,心胸比缩小,LVEF提高,与治疗前相比差异有显著意义(P<0.05),亦优于对照组(P<0.05),而对照组治疗后心率减慢,心胸比缩小,LVEF提高,但与治疗前相比差异无显著意义(P>0.05)。结论:雅施达与倍他乐克联合治疗CHF可明显使病人的心率减慢,血压下降,心胸比率缩小,LVEF提高。

Objective： To investigate the influence of acertil combined with betaloc on the cardiac function in patients with congestive heart failure （CHF）. Methods：Seventy five patients with CHF were divided into two groups： The control group and therapeutic group. The control group was treated with routine therapy including digoxin, diuretics and so on. The therapeutic group was treated with acertil and betaloc on the basis of routine therapy. Both groups were treated for 12 weeks. Results： The heart rate, blood pressure level and heart chest ratio decreased （P〈0.05）, the left ventricular ejection fraction （LVEF） increasted （P〈0.05） in therapeutic group. However the improvement of above index was not significant before and after treatment in the control group. Conclusion.. Acertil combined with betaloc can decrease heart rate, blood pressure and heart chest ratio and raise LVEF in patients with CHF.