乌梅透骨口服液抗炎镇痛活血作用的药效学

Effects of Wumei tougu oral solution on anti-inflammation,analgesia and invigoration of blood circulation in animals

目的:观察乌梅透骨口服液(WTOL)的抗炎、镇痛和活血化淤作用。方法:采用二甲苯致耳肿胀实验、腹腔毛细血管通透性实验、角叉菜胶致足跖肿胀实验和棉球肉芽肿实验观察该药的抗炎作用;采用扭体实验和热板实验观察WTOL的镇痛作用;建立血淤模型观察该药的活血作用。结果:WTOL能显著抑制二甲苯所致的耳肿胀、降低腹腔毛细血管通透性、抑制角叉菜胶引起的足跖肿胀和棉球所致的肉芽肿(P<0.05);对醋酸引起的扭体反应有显著的抑制作用,并能明显提高小鼠热板痛阈(P<0.05);能降低血淤模型大鼠的血液黏度及红细胞压积(P<0.05)。结论:WTOL对实验动物模型具有明显的抗炎、镇痛及活血作用。

OBJECTIVE To investigate the effects of Wumei tougu oral solution（WTOS） on anti-inflammation, analgesia and invigoration of blood circulation in animals. METHODS Models of acute inflammatory reaction were studied by dimethyl benzene-induced ear edema, acetic acid-induced elevation of celiac capillary＇s permeability and carrageenin-induced paw edema. Chronic inflammatory reaction was studied by cotton ball-induced granulorna. Writhing test and hot-plate test were used to study analgesic effects. Blood stasis model was established to study hemorheological effect. RESULTS WTOS could significantly suppress dimethyl benzene-induced ear edema, acetic acid-induced elevation of celiac capillary permeability, carrageenin- induced paw edema and cotton ball-induced granuloma（P〈0. 05） ; It could inhibit the writhing times induced by acetic acid and raise the pain threshold of heat stimulation（P〈0. 05）; It could significantly lower the viscosity of blood and volume packed cells（P〈0. 05）. CONCLUSION WTOS has remarkable anti-inflammatory and analgesic effects, it can also invigorate blood circulation.