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人食管癌组织中β_1-整合素mRNA的表达及其意义

Expression and significance of β_1-integrin mRNA in human esophageal cancer
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摘要 目的:研究β_1-整合素(β_1-integrin)在人食管癌组织中的表达及其与食管癌的临床病理关系.方法:采用RT-PCR方法检测30例人食管癌组织及癌旁正常食管组织中β_1-integrin的表达.结果:食管癌组织及癌旁正常食管组织中都有不同程度β_1-integrin的表达,并且前者明显高于后者(1.205±0.379 vs 0.470±0.166,P=0.003);伴有淋巴结转移者食管癌组织β_1-integrin表达量明显高于无转移者(1.534±0.229 vs 0.998±0.160,P=0.023).随食管癌分期增高,β_1-integrin mRNA表达量也不断增高.结论:β_1-integrin可能在食管癌细胞的恶性生物学行为中具有重要的作用. AIM: To ingestigate the expression of β1- integrin in human esophageal carcinoma and its correlation with clinical pathology. METHODS: The expression of β1-integrin mRNA was detected in 30 cases of esophageal carcinoma and cancer-adjacent tissues by re- verse transcriptase polymerase chain reaction (RT-PCR). RESULTS: The expression of β1-integrin mRNA in esophageal carcinoma tissues was signifi±cantly higher than that in the normal esophageal tissues (1.205 ± 0.379 vs 0.470 ± 0.166, P = 0.003), and it was also markedly higher in the cases with metastasis than that in the ones without metastasis (1.534 ± 0.229 vs 0.998 ± 0.160, P 0.023). With the elevation of histological grading, the expression of β1-integrin mRNA was also increased. CONCLUSION: β1-integrin may play an impor tant role in the malignant biological behavior of esophageal carcinoma.
出处 《世界华人消化杂志》 CAS 北大核心 2007年第12期1446-1448,共3页 World Chinese Journal of Digestology
关键词 食管癌 Β1-整合素 逆转录-聚合酶链式反应 Esophageal carcinoma β-integrin Re-verse transcription-polymerase chain reaction
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