摘要
对氧磷酶(paraoxonase,PON)家族是由PON 1,PON 2,PON 3三大成员组成的。三者在分子结构、基因结构及生物学特性上都有很多相似性。对氧磷酶最重要的生物学特性是抗氧化性,这与许多疾病的发生发展有关。目前的研究已经肯定对氧磷酶具有抗心血管疾病(主要是动脉粥样硬化、冠心病)的作用,但是这种关系主要是由PON 1活性决定的,而与PON 1的基因多态性关系不大。对氧磷酶的活性与糖尿病(DM)及其并发症的发生呈负相关,但是其基因型与DM的关系还需要有更多的研究来证实。吸烟可以降低血清对氧磷酶的活性和浓度,酒精对PON的影响与酒精的摄入量有关,而维生素E等影响的研究结论尚不一致,需要进行更多的实验。
The paraoxonase family consists of three members （PON1 ,PON2 and PON3）that shape structural properties and enzymatic activities ,among which is the ability to hydrolyze oxidized llpids in LDL. There is a relationship between its antioxidant ability and many diseases. Lip to date ,it is proved that PON1 activity inhibits the development of cardio-vascular diseases such as arteriosclerosis （AS）and coronary heart disease （CHD）. But the influence of PON gene polymorphlisms is still uncertain in the terms of diabetes mellitus. Besides gene polymorphlisms,smoking can decrease the concentration and activity of PON,while the influence of alcohol depends on its amount. In addition,more studies should be taken to identify the roles of factors such as vitamin E in regulating the paraoxonase,
出处
《现代检验医学杂志》
CAS
2007年第3期91-94,共4页
Journal of Modern Laboratory Medicine
关键词
对氧磷酶
心血管疾病
糖尿病
阿尔茨海默病
paraoxonase
cardio-vascular diseases
diabetes mellitus
Alzheimer Disease
