糖尿病视网膜病变相关血液检测指标

Analysis of the correlation between diabetic retinopathy and related serum levels

目的:探询与糖尿病视网膜病变发生发展相关的可定量血液检测指标,以便对发生增殖性糖尿病视网膜病变的高危患者进行监测,为适时的预防性激光光凝治疗提供依据。方法:抽取无增殖期糖尿病视网膜病变的糖尿病患者、增殖期糖尿病视网膜病变患者及无糖尿患者群静脉血,检测糖化血红蛋白(HbA1c)、血清C反应蛋白(CRP)及血管粘附因子(sICAM-1)水平,比较各组之间统计学差异。结果:HbA1c水平在正常对照与糖尿病患者之间有显著性差异,在无增殖期糖尿病视网膜病变的糖尿病患者组与增殖期糖尿病视网膜病变患者组之间无显著性差异,正常对照分别与另两组比较均有显著性差异。CRP水平在增殖期糖尿病视网膜病变患者组与另两组均有统计学差异。sICAM-1水平各组比较无显著性统计学意义。结论:血HbA1c和CRP水平可能对糖尿病视网膜病变发生和发展有提示意义。

AIM： To investigate some quantitative serum factors related to diabetic retinopathy so as to inspect the high risk of proliferative diabetic retinopathy and to carry out retinal photocoagulation therapy in time. METHODS： The serum levels of hemoglobin A1c （HbA1c）, C-reactive protein （CRP） and intercellular adhesion molecule-1 （sICAM-1） were measured respectively in diabetics patients with and without proliferative diabetic retinopathy as well as normal people. The data were analyzed between the three groups. RESULTS： The level of HbAlc in normal group were significantly lower than that in diabetics groups （P〈0.005）, but there was no significant difference between the diabetic groups with and without proliferative diabetic retinopathy. The level of CRP in proliferative diabetic retinopathy patients were significantly higher than the other two groups （P〈0.01）. There was no significant difference on the level of sICAM-1 between the three groups. CONCLUSION： The level of HbA1c and CRP may play important roles in reflecting the progress of diabetic retinopathy.