药物性角膜病变的临床分析

Clinical analysis of drug toxic keratopathy

目的:探讨药物性角膜病变的临床特征,以提醒临床医生注意,预防此类疾病的发生。方法:对临床所见24例34眼药物性角膜病变的临床资料进行回顾性总结分析。结果:角膜病变轻者,短期用药即可恢复角膜上皮混浊水肿消退,角膜透明视力增加。角膜病变重用药时间长者,大约2～4wk才可完全恢复。结论:药源性角膜病变多由眼局部不合理用药引起,其临床表现多为非特异性,不同滴眼剂所致角膜毒性的发病机制不尽相同,临床眼科医生应关注滴眼剂对角膜的毒性作用,并积极预防和治疗,规范用药、预防发生是关键。

AIM： To study the clinical features of drug toxic keratopathy so as to raise the attention of doctors on its prevention. METHODS： The clinical data of 24 cases （34 eyes） with drug toxic keratopathy were retrospectively analyzed. RESULTS： The drug toxic keratopathy is mainly caused by improper local drug usage with non-spedfity as its major dinical manifestation. CONCLUSION： Since the mechanisms of keratopathy caused by different drugs vary each other, doctors should pay attention to the toxicity of eye drops on the cornea, and standardized durg usage and proper prevention are the keys to active treatment of the drug toxic keratopathy.