324例大泡性角膜病变病因分析

Etiology for bullous keratopathy in 324 cases

目的分析大泡性角膜病变的致病原因。方法回顾性分析2000年1月至2005年l2月间我院收治的大泡性角膜病变患者的临床资料,共324例(343只眼),男190例(202只眼),女134例(141只眼),对其致病原因和构成比进行分析。结果在大泡性角膜病变病因中:先天性因素37只眼(10.78%);后天性因素中机械性损伤226只眼(65.89%),其中手术源性损伤185只眼;角膜移植术后内皮细胞功能失代偿46只眼(13.41%);青光眼29只眼(8.45%);病毒性角膜炎5只眼(1.46%)。发病前有多次手术史者(包括2次及2次以上者)70只眼(20.41%)。结论后天机械性损伤是大泡性角膜病变最常见的原因,主要为手术源性损伤。

Objective To study etiology for bullous keratopathy. Methods We retrospectively performed a chart review of the hospital reeords of all patients （ 343 eyes ） experieneed bullous keratopathy at Shandong Eye Institute during a 6 year period （2000 - 2005 ）. The etiology, history of operations and so on were discussed. Results Of the 324 eases （343 eyes ） ineluded, Thirty-seven eyes （10.78%） were for congenital eorneal eonditions, 226 eyes （65.89%） had ae- quired mechanical trauma, 46 eyes （13.41% ）were for corneal deeompensation, 29 eyes （8.45% ） were glaueoma, 5 eyes （ 1.46%） were herpes simplex keratits. History of multiple operations oceurred before the onset of bullous keratopathy in 70 eyes （20.41%）. Conclusion Mechanical trauma was considered as the most common reason for bullous keratopathy, especially, the trauma eansed by surgery.