复方樟柳碱II号治疗眼外肌麻痹临床观察

Clinical research in treatment ophthalmoparalysis with compound anisodine hydrobromide II

目的：观察复方樟柳碱Ⅱ号治疗眼外肌麻痹的临床效果。方法：将40例（40只眼）后天性眼外肌麻痹患者（已排除颅内占位及脑梗塞、重症肌无力）随机分为复方樟柳碱Ⅱ号治疗组及激素联合维脑路通对照组，每组各20例（20只眼）。治疗组用复方樟柳碱Ⅱ号2ml行患眼颞浅动脉旁皮下注射，每天1次，10d为1个疗程，根据病情连续治疗2～4个疗程；对照组口服强的松20mg，每天1次，口服维脑路通200mg，每天3次，10d为1个疗程，根据病情连续治疗2～4个疗程；观察两组病例复视消失时间、眼位及眼球运动恢复情况。结果：治疗组20例中治愈18例（90％），好转1例，无效1例，总有效率95％；对照组20例中治愈12例（60％），好转5例，3例无效。两组治愈率有显著性差异（P〈0．05）。结论：复方樟柳碱Ⅱ号治疗眼外肌麻痹能明显提高治愈率，无并发症，安全有效。

Objective Review the effect of compound Anisodine Hydrobromide II in treatment ophthalmoparalysis. Methods 40 cases of acquired ophthalmoplegia （ exclusion Intracalvarium and rhinopharynx desease, myasthenia gravis ） were invided into 2 groups in random. Therapy group use compound Anisodine Hydrobromide Ⅱ and control group use troxerutin; venoruton respective. 20 cases each group. Therapy group carry out arterial temporalis superflcialis side hypodermic injection in trouble eye with 2ml compound Anisodine Hydrobromide Ⅱ, qd, 10 days a course, carrry out 2 ～4 course based on patient＇s condition. In control group, carry out predrdsone 20mg, oraly,qd, and venoruton 200mg, t. i. d, 10 days a course. To observe the diplopia extinction time, position of eye and ocular movement recover status. Results In therapy group, curing 18 cases （90%）, improve 1 cases, inefficacy 1 cases, total effective rate is 95%. In Control group, curing 12 cases （60% ） , improve 5 cases, inefficacy 3 cases, total effective rate is 85% . The cure rate was significant difference between 2 groups. Conclusion Treatment with compound Anisodine Hydrobromide Ⅱ is a safe way for ophthalmoparalysis, it can raise cure rate and has no complication.