造影剂对重症急性胰腺炎胰腺微循环的影响

The Effects of Contrast Medium on the Pancreatic Microcirculation in Rats with Severe Acute Pancreatitis

目的对重症急性胰腺炎(SAP)动物模型静脉注射临床上常用的造影剂后进行病理学分析,测量胰腺血流量,探讨造影剂对重症急性胰腺炎胰腺微循环的影响。方法选用健康W istar雄性大鼠,制备重症急性胰腺炎模型后,分为4组(每组6只):重症急性胰腺炎组、重症急性胰腺炎注射生理盐水对照组、重症急性胰腺炎注射76%泛影葡胺组、重症急性胰腺炎注射优维显300组。对胰腺组织的病理学评分并测量胰腺血流量,采用SPSS 10.0软件对数据进行统计学分析。结果重症急性胰腺炎注射造影剂组、注射生理盐水对照组与重症急性胰腺炎组比较差异无统计学意义;重症急性胰腺炎注射造影剂组,组间比较差异无统计学意义。结论造影剂对重症急性胰腺炎胰腺微循环没有产生负面作用,不会加重急性胰腺炎病情。

Objective As a good diagnostic means, contrast-enhanced computed tomography （CECT） has been used for evaluating acute pancreatitis, but, it is uncertain whether the contrast medium（ CM）, which must be used in CECT, has adverse effects to the microcireulation of pancreas with severe acute pancreatitis（SAP）. The purpose of this study is to observe the effects of contrast media on microcireulation of pancreas with SAP by measuring volume of blood flow and evaluating changes in pathology of pancreas in rat SAP models, which has been intravenously injected CM. Methods SAP models of wistar rats were divided into 5 groups randomly： control group, SAP group, SAP with normal saline injecting group, SAP with 76% Cardiografin injecting group and SAP with uhravist-300 injecting group. Then, volume of blood flow into the pancreas was measured and changes in pathology were evaluated to show the influence of CM on microcirculation of pancreas with SAP. Results Comparing with SAP group, the other 3 groups had no significant differences on volume of blood flow and pathologic changes（ P 〈 0.05 ） , and there was no significant difference among the 4 study groups（ P 〉 0.05 ）. Conclusion This study shows that CM has no adverse effects on the microcirculation of rat pancreas with SAP and would not worsen the disease.