鱼腥草制剂抗炎动物模型的建立及研究

The Establishment of Animal Model and Studies on the Effect of Anti-inflammation of Houttuynia cordata Thunb

目的建立鱼腥草制剂抗炎动物模型。方法耳根皮下注射制剂、小鼠耳二甲苯致炎、耳圆片称重建立炎症模型,检验鱼腥草制剂的抗炎效果。结果二甲苯最佳致炎时间为1 h;鱼腥草制剂在小鼠体内作用约2 h时对致炎鼠疗效最好;给药次数为第6次时,小鼠耳肿胀度最小;以80μl/20 g的剂量给药组肿胀度抑制率最大,建立了鱼腥草制剂鼠耳肿胀法抗炎动物模型。结论鱼腥草制剂鼠耳肿胀法抗炎动物模型可用于鱼腥草制剂药效研究。5种鱼腥草制剂均有明显的抗炎效果,其中8号制剂抗炎效果最好。

Objective To establish the animal model of the anti - inflammatory properties of Houttuynia cordata Thunb. Methods To make the inflammation model via injecting preparation into hypodermic, inducing mice ear edema by xylene, and ear wafer - weighting. Then test the effects of anti - inflammation of Houttuynia cordata Thunb. Results The best inducing mice ear edema time for xylene was lh and the effect of anti - inflammation of the preparation reached the best after injected 2h. When the mouse had been injected with preparation for 6 times, the degree of edema was the lowest. When the mouse had been dosed with 80 μl/ 20 g, the degree of edema inhibition was the highest. The animal model of the anti - inflammatory properties of mice ear turgidity of Houttuynia cordata Thunb. preparation was established. Conclusion The animal model of the anti - inflammation is an ideal model for studying Houttuynia cordata Thunb. The five kinds of Houttuynia cordata Thunb. preparations have obvious anti - inflammatory effect on mice in which the number eight was the best.