以高敏C-反应蛋白作为动脉粥样硬化气虚血淤病机辨证的标志物的理论探讨

Study on Hs-CRP as the Marker of Pathogenesis of Qi-deficiency and Blood-stagnation in Atherosclerasis

动脉粥样硬化(AS)是一种炎性疾病,主要以潜证方式存在于健康人群,气虚血瘀是AS潜证的病机关键。CRP参与了AS炎症发生发展的全过程,并是AS相关心脑血管疾病的独立危险因素和预测指标,因此,我们提出以hs-CRP作为AS气虚血淤病机辨证的筛查指标,高hs-CRP的患者如果AS的常规检查异常,建议结合病人体质应用益气活血法辨治预防AS。该项工作将有助于开展AS的中医防治工作,深化中医的治未病思想。

AS is an inflammatory disease which exists in ＂ healthy＂ people as a dormant syndrome. Qi-deficiency and Bloodstagnation is the main pathogenesis of AS. C-reactive protein （CRP） participates in the occurrence and progress of AS. It is the independent risk factor and prognostic index of AS. We propose that high sensitivity CRP （hs-CRP） should be the screen marker of pathogenesis of Qi-deficiency and Blood-stagnation. If the high hs-CRP case have abnormality in routine examination of AS, We suggest that use the treatment based on syndrome differentiation based on replenishing Qi and activating blood circulation which combined with the pathogenesis and the physic of the patient. This work would help to prevent and therapy AS with TCM and deep the orinciole of ＂oreventive treatment before the occurrence of diseases＂.